ivive.app

{
  "mcpServers": {
    "app.ivive/ivive": {
      "url": "https://api.ivive.app/mcp/"
    }
  }
}

Indexed tools

Tool metadata and schemas come from the remote server and are untrusted. Indexing only lists tools; it never calls them.

6 shown · authentication unknown

• calc_clhep

  Hepatic and plasma clearance from in-vitro CLint, fu,mic and fu,p (IVIVE), with the observed-CL band and applicability warnings. If fu,p or fu,mic came from predict_inputs, tell the user the result rests on predicted inputs.

  Schema valid · SHA-256 7293d203ca61…

  View input schema

  {
    "type": "object",
    "properties": {
      "clint": {
        "description": "Intrinsic clearance (µL/min/mg microsomal protein). Use ge=0: zero clearance is physiologically valid.",
        "minimum": 0,
        "title": "Clint",
        "type": "number"
      },
      "fu_mic": {
        "description": "Unbound fraction in microsomes (0–1). Corrects for non-specific microsomal binding.",
        "exclusiveMinimum": 0,
        "maximum": 1,
        "title": "Fu Mic",
        "type": "number"
      },
      "fu_p": {
        "description": "Unbound fraction in plasma (0–1). Plasma protein binding correction.",
        "maximum": 1,
        "minimum": 0,
        "title": "Fu P",
        "type": "number"
      },
      "rb": {
        "default": 1,
        "description": "Blood-to-plasma concentration ratio. fu_b = fu_p / Rb. Output is blood clearance.",
        "exclusiveMinimum": 0,
        "maximum": 50,
        "title": "Rb",
        "type": "number"
      },
      "species": {
        "description": "Species for physiological parameters (Qh, MPPGL, liver weight).",
        "enum": [
          "human",
          "rat",
          "dog"
        ],
        "title": "Species",
        "type": "string"
      },
      "model": {
        "default": "well-stirred",
        "description": "IVIVE model. well-stirred (venous equilibrium) or parallel-tube (sinusoidal perfusion).",
        "enum": [
          "well-stirred",
          "parallel-tube"
        ],
        "title": "Model",
        "type": "string"
      },
      "assay_type": {
        "default": "microsomes",
        "description": "Assay type for CLint scaling. microsomes: uses MPPGL (mg/g) × 1e-3; hepatocytes: uses HPGL (×10⁶ cells/g) × 1e-3.",
        "enum": [
          "microsomes",
          "hepatocytes"
        ],
        "title": "Assay Type",
        "type": "string"
      },
      "correction_id": {
        "anyOf": [
          {
            "format": "uuid",
            "type": "string"
          },
          {
            "type": "null"
          }
        ],
        "default": null,
        "description": "Saved lab correction (/api/correction-equations) to apply. Must match species and assay_type. Corrects predicted plasma CL and replaces the reference band with one from the lab's compounds.",
        "title": "Correction Id"
      },
      "clint_censored": {
        "default": false,
        "description": "Set when the assay reported CLint below its limit of quantification and `clint` is that limit rather than a measurement. CLint then lies in [0, clint), so every clearance output is an upper bound: `upper_bound` is true, no observed-CL band is returned, and the clint_below_loq flag fires.",
        "title": "Clint Censored",
        "type": "boolean"
      }
    },
    "required": [
      "clint",
      "fu_mic",
      "fu_p",
      "species"
    ],
    "title": "CLhepRequest"
  }